Immunoglobulin G

Immunoglobulin G

IgG is an isotype of antibodies produced and secreted by plasma B cells. Its structure,as seen in the accompanying image, consists of two identical heavy and two identical light chains (4 polypeptides in all), connected by disulfide bridges. Each IgG monomer has two antigen binding sites which facilitate the attachment of varying pathogens and causing agglutination, whereupon attack by phagocytic cells is mediated. IgG is the only antibody which can cross the placenta thereby conferring some form of immunity to the foetus in utero.

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