Lambert-Eaton Myasthenic Syndrome

Image

LEMS, as the title above is abbreviated to, is a neuromuscular junction disease characterized by muscle weakness of the limbs due to autoimmune effects,namely the attack by antibodies of the calcium gated voltage channels of the junction. Less acetylcholine can be transmitted across the synaptic cleft thereby leading to irregular or no  muscle contraction. Autonomic disorders also result as Ach is a vital neurotransmitter across the CNS as well. Treatment includes the use of pyridostigmine which decreases Ach degradation, potassium channel blockers which delay repolarization of the nerve terminals, chemotherapy and administration of IgG.

This entry was posted in Chem Path. Bookmark the permalink.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s