Lambert-Eaton Myasthenic Syndrome


LEMS, as the title above is abbreviated to, is a neuromuscular junction disease characterized by muscle weakness of the limbs due to autoimmune effects,namely the attack by antibodies of the calcium gated voltage channels of the junction. Less acetylcholine can be transmitted across the synaptic cleft thereby leading to irregular or no  muscle contraction. Autonomic disorders also result as Ach is a vital neurotransmitter across the CNS as well. Treatment includes the use of pyridostigmine which decreases Ach degradation, potassium channel blockers which delay repolarization of the nerve terminals, chemotherapy and administration of IgG.

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