Amyloidosis results from the abnormal deposition of insoluble proteins in various tissues. The insoluble protein aggregates are known as amyloids and are caused dy disruption of the protein’s secondary structure causing the insolubility and makes them unable to be degraded by proteolysis(the beta sheet structure is affected and is hydrophobic forming clusters which are stabilized by glycosaminoglycans and serum amyloid P).

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