Category Archives: Chem Path

Duchenne Muscular Dystrophy (Genetic Disease)

A recessive X-linked form of muscular dystrophy affecting boys caused by a mutation in the dystrophin gene which codes for a vital muscular protein(dystrophin) that provides structural integrity to the dystroglycan complex of the cell membrane. Muscle degenration occurs and … Continue reading

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AMYLOIDOSIS

Amyloidosis results from the abnormal deposition of insoluble proteins in various tissues. The insoluble protein aggregates are known as amyloids and are caused dy disruption of the protein’s secondary structure causing the insolubility and makes them unable to be degraded … Continue reading

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Lambert-Eaton Myasthenic Syndrome

LEMS, as the title above is abbreviated to, is a neuromuscular junction disease characterized by muscle weakness of the limbs due to autoimmune effects,namely the attack by antibodies of the calcium gated voltage channels of the junction. Less acetylcholine can … Continue reading

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Alzheimer’s Disease Alzheimer’s disease is characterised by a progressive loss of cognitive function with concomittant increase in neuropsychiatric and behavioural changes.  Essentially the synaptical transmission of neurotransmitters, vital for the relaying of electrical impulses that convey information across the central … Continue reading

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